Intralexical
> The team then smeared the yellow dye on a mouse’s underbelly, making the abdominal skin see-through and revealing the rodent’s intestines and organs.

> The procedure has not yet been tested on humans and researchers will need to show it is safe to use, particularly if the dye is injected beneath the skin.

How did they resist the urge to sneak a peak at their own arm or one of their fingers?

andai
I read a short story in my youth -- it must have been by Paul Jennings -- about a boy who got bit by a weird bug. His skin turned transparent and he had to go live in a cave.

Many years go by and he gets bit again and his skin goes back to normal. He finally returns to society, only to find that everyone has gone transparent, and he is once again an outcast...

smeej
I know they say "not tested in humans," but I don't think anybody's going to convince me nobody in the lab tried it out when they thought nobody was looking, unless there's some really obvious (to experts) reason to assume this won't work in humans.
alwa
I’m surprised that this characteristic of an extremely common dye—being used in its main application, as a dye—hasn’t been described before. Surely there’s some limitation that’s obvious to those skilled in the chemical and biological arts?

Or is it really just a matter of serendipity waiting til now to lead anybody down the path of trying it this way?

_Microft
Paper: „Achieving optical transparency in live animals with absorbing molecules“, https://www.science.org/doi/10.1126/science.adm6869
alentred
It is fun to imagine how my intestines become transparent every time I drink Fanta and there is no one to see it but the microbes living there. Who probably "freak out" in their own way.
arcticbull
From the article, the dye is tartrazine -- FD&C Yellow 5 or E102.
pvaldes
Never tested on humans

Some tropical American frogs evolved to do it naturally (fam Centrolenidae). Some fishes also can do it also in a few different orders (Siluriformes and Perciformes at least), so in lower vertebrates it is possible and evolved several times.

But they have a different metabolism than ours and a mouse skin is much more thin than our own skin. I assume that this effect will work only on very small animals and the optical effect will hit some thickness limit somewhere. Could work on fingers but not in heart. At this moment my hype level is a 4 over 10.

sschueller
> while smearing it on the rodent’s scalp allowed scientists to see blood vessels in the animal’s brain.

Since when do mice not have skulls?

sans_souse
I just got my Doritos dry rub on, followed by a Sunny D Shower, and now nobody can see me.
moribvndvs
In Doritos? How are call of duty players not constantly transparent?
ardrak
> At the moment, transparency is limited to the depth the dye penetrates, but Hong said microneedle patches or injections could deliver the dye more deeply.

Reverse tattoos incoming.

teeray
I’ve seen this movie. It doesn’t end well for Kevin Bacon.
billfor
Some countries have banned it in humans, due to health concerns. https://www.verywellhealth.com/tartrazine-free-diet-83227
justinclift
Wonder if this has potential for internal imaging too?

For example, with an endoscope or other thing that checks internal passageways. Applying this stuff (or whatever is appropriate to the given organ) could potentially allow the optical visibility of more stuff.

skibz
I'm quite interested in how the use of tartrazine has been regulated around the world.

In my home country, for example, it's not permitted for use in food. Many other places, however, allow this.

jjkaczor
Halloween is about to become even more weird...
egypturnash
Huh, I never expected to find out that the Ghouls from Leiber’s Fafhrd and the Grey Mouser books were actually plausible.

(They were perfectly normal medieval fantasy humans, except for their flesh and organs being mostly transparent, so you just saw a pinkish skeleton with a faint shimmer around it.)

adamredwoods
I wonder if this would improve Digital Optical Spectroscopy for cancer detection and monitoring?

Also related: https://www.ycombinator.com/companies/eden-2

azinman2
Truly wild. This could be an amazing advancement if true and safe!
moralestapia
It says it's never been tested on humans and the proper diligence should follow,

But given that we already eat large amounts of it with no harmful side effects, the expectations are good.

dghughes
Basically reverse sunblock. Ouch! I wonder how light affects internal organs. Skin is meant to be a protective barrier.
bookofjoe
>Achieving optical transparency in live animals with absorbing molecules

https://www.science.org/doi/10.1126/science.adm6869

pvaldes
<s>Hey Tiktokers, who needs a stupid dye? Show your inner light. Swallow our new gastrosubmarine led pill and shit bright like a diamond.<s/>
bdcravens
Strange dating moment:

"I really do have a good heart!" (takes off shirt, take out a bottle of dye, and smear it on torso) "See, just look at it!"

starkparker
Some practical VFX artists are gonna go wild with this
D-Coder
The Washington Post's headline for this article is:

Scientists use food dye found in Doritos to make see-through mice

My first reaction was, what the heck have I been smoking?

freen
Awesomest Halloween ever.
tiahura
Don’t mice have skulls?
swayvil
Halloween costume!
rbanffy
This solves my Halloween costume for this year.
m3kw9
Can’t wait till it becomes a trend on instagram
aster0id
New kink incoming
kragen
specifically tartrazine in only the red part of the spectrum. can this be real?
roshankhan28
what are we trying to achieve with making skin transparent? I dont see a use case. anyone want to help me with it? please tell me more about it.
seydor
introspective people eat doritos
wordsinaline
Anyone want to sell me some tartrazine?
ImHereToVote
Imagine this as face cream at a rave.
evan_
When my little brother was 3 or 4 he stepped on a nail in our yard, probably dropped during some recent construction. It went all the way through his poor little foot, straight through, out the top. I can see it, vividly, in my mind's eye. Mom scooped us up and rushed us, still barefoot, to the ER. I remember him being almost calm- not the way I would have reacted. They x-rayed his foot and soaked it in a tub of what I now know to be iodine to kill bacteria. I remember this clearly: it was the first time I'd ever seen an x-ray in real life, rather than just in alphabet books.

Fortunately the nail totally missed anything important, so they just pulled it out and bandaged him up- no worse for the wear. He went on to be an honest-to-God track star so it obviously didn't have any lasting effect.

Decades later we were talking about something and he said to me, "Why don't they use that x-ray water anymore?". I had no idea what he was talking about so I asked him to elaborate.

The way he remembers the incident is that they put his foot into a bucket of amber liquid and, once submerged, his skin became transparent. He looked in and saw his own bones, blood vessels, and- in the middle of it all- the nail that was causing such a fuss. He described wiggling his toes, flexing his ankle, and seeing the bones and tendons move, directly, with his own eyes.

His toddler brain, probably in shock, had combined the x-ray film and iodine bath. Over the years it had grown more detailed and reinforced. He described it with such clarity that I almost wondered if I hadn't been mistaken. He didn't believe me when I told him how I remember it. We called our mom who confirmed my version of events, plus did some googling, which finally convinced him.

Anyway I just sent him this article. It's interesting that not only is the x-ray water he remembers theoretically possible, it would actually be amber.

tampontim
[flagged]
ranger_danger
Absorbing anything that ends in -zine into the body does not sound safe.