https://www.reddit.com/r/DMT/comments/gb9ar0/dark_dmt_trip_r...
This doesn’t get mentioned in the current “psychedelics as a cure-all” hype wave.
Recalling my mushroom days.... Okay, I think I get it. Psychedelic experience is, in part, about embracing the beautiful chaos of the universe. Surrendering to the charms of free-flowing wild information at scale so huge there's no chance of imposing your own orderly corrections - as you might in normal every day life via OCD. That's my armchair take anyway.
Psychiatric history | Negative responders (%) | Non-responders (%) | Positive responders (%)
OCD | 0.0 | 25.0 | 75.0
I have been taking psychedelics for 50 over years. I am retired psychotherapist and I do not have a predisposition to mental ill health. I was also a substance misuse worker and methadone dispenser for over 10 years. I gave up smoking hash when I was 40 years old.
I did notice that with the introduction of skunk and the increase of up to 20% more Tetrahydrocannabinol (THC), there were more and more people being sectioned under the mental health act with psychosis. Whereas prior to skunk when people generally smoked good old fashioned, Moroccan, Lebanese and Afghani hashish it was a rarity.
I know a range of people of different ages who partake in psychedelic use and have no trouble, like me, in holding down a professional job role and engaging fully in life.
As with all drugs there is a risk, however, the risks with Psyceedelics are very low in comparison with other drugs.
We must not use individual cases to determine the safety of any drug.
Here in the UK the media went wild over reports that a 18 year old girl (Leah Betts) had died from taking MDMA. Very rarely are the true facts given; The coroner said that "water intoxication", and not an allergic reaction to the drug, was the cause of death.
I have a great deal of respect for Professor David Nutt who is an English neuropsychopharmacologist specialising in the research of drugs that affect the brain and conditions such as addiction. His recommendations to the government to reclassify drugs were rejected and he was sacked.
heroin is top of the list - alcohol is 5th on the list - LSD is 14th on the list - Ecstacy is 18th on the list
“they should have known they had a family history of schizophrenia before using it!”
every dismissive psychedelic user that brags about increased empathy in the next breath
but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informed risks
Controlling for the substance and amount as well as having a professional, caring guide to help the patient through the experience will be a FAR different experience than eating a fist-full of shrooms at a party some stranger gave you while under the influence of other things...
I think there's a clear bias in cases of big pharma approved meds to jump to "Oh, it wasn't the medication, the condition just worsened" and with psychedelics/weed to jump to "The substance use is causing this". Even when there is proof of RX medication worsening mental health conditions, it's common to have these relationships straight up denied by the prescribing doctor.
This isn't to say that there isn't a similar relationship in psychedelics, but it feels really disingenuous to me to be mentioning this outside of the wider context of psychiatric meds which somehow get a free pass for causing a much wider and dangerous range of side effects. If psychedelics cause less harm than commonly prescribed drugs in the same population, isn't that a good thing? We should understand these harms, but the bias of Big Pharma needs to be taken out of the picture.
Feels like another publish or perish paper.
That said, I think it's a refreshing perspective, and it seems like a good idea to look at effect heterogeneity in psychedelics use. Thinks like bayesian trees (BART) can help identify subgroups that react differently to stimuli along specific characteristics.